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platelet rich plasma prp injection therapy regenerative medicine


Experience the power of the most potent Platelet Rich Plasma



Platelet Rich Plasma: A Regenerative Solution for Musculoskeletal Conditions


If you suffer from chronic pain or injury in your joints, tendons, ligaments, or nerves, you may have heard of platelet rich plasma (PRP) as a potential treatment option. PRP is a form of regenerative medicine that uses your own blood to stimulate healing and repair of damaged tissues. PRP has been shown to be effective for various musculoskeletal conditions, such as osteoarthritis, tendinopathy, ligament sprains, and nerve entrapments.


But not all PRP is created equal. There are many factors that affect the quality and efficacy of PRP, such as the concentration, composition, growth factor concentration and the way it is delivered.


Over the past 10 years, OrthoRegen® has been at the forefront of research and development regarding PRP and we have invested countless time and funding into perfecting the nuances of PRP.  This has led to the most advanced platelet-based therapy in Australia, our proprietary PRP formulation called CYTO-X PRP.


How is PRP created and how does it work?


PRP is a blood product that is obtained by spinning a small sample of your blood in a centrifuge. This separates the blood into different layers, such as red blood cells, white blood cells, plasma, and platelets. The platelet layer, which contains a high concentration of growth factors and cytokines, is then extracted and injected into the injured area. The growth factors and cytokines are signalling molecules that activate the body's natural healing response, stimulating the regeneration of new cells and tissues.


PRP can be used to treat various musculoskeletal conditions, such as:

  • Osteoarthritis: PRP can reduce inflammation, pain, and stiffness in the affected joint, as well as improve cartilage quality and function.

  • Tendinopathy: PRP can enhance tendon healing and repair, as well as reduce pain and improve function.

  • Ligament sprains: PRP can accelerate ligament healing and recovery, as well as prevent chronic instability and laxity.

  • Nerve entrapment: PRP can reduce nerve inflammation and swelling, as well as improve nerve conduction and sensation.


What makes PRP effective?


The effectiveness of PRP depends on several factors, such as:

  • The concentration of platelets: The higher the concentration of platelets, the more growth factors and cytokines are delivered to the injured area. A higher concentration of platelets also means a higher viscosity of the PRP, which can improve its retention and distribution in the tissue.  As you get older, higher doses of platelets within the PRP are needed.  Research suggests approximately 10 billion platelets per 7mls of PRP.  This can not be achieved by simple, test tube PRP systems that most physicians are currently using in Australia.

  • The composition of platelets: The platelets in PRP can vary in their size, shape, and function. Smaller and younger platelets tend to have more growth factors and cytokines than larger and older platelets. The composition of platelets can also be influenced by the presence or absence of white blood cells, which can have pro-inflammatory or anti-inflammatory effects depending on the type and amount.

  • The delivery of platelets: The delivery of PRP to the injured area is crucial for its effectiveness. The delivery method should ensure that the PRP reaches the target tissue with minimal loss or leakage. The delivery method should also be guided by imaging techniques, such as ultrasound or fluoroscopy, to ensure accuracy and safety.

  •  Some regularly used local anaesthetics can negatively impact platelets. Only one type of local anesthetic has been found to have no effect on platelet health or function. Unfortunately, most other clinics offering PRP therapy are ignorant of this knowledge. OrthoRegen® only employs a local anesthetic that has little no effect on platelets.


Introducing CYTO-X PRP - how is it different?


CYTO-X PRP is OrthoRegen’s proprietary formulation of PRP.  CYTO-X PRP combines high dose PRP, autologous concentrated growth factors and cytokines, and low molecular weight, highly cross-linked hyaluronic acid. This combination results in the most potent form of platelet therapy in the world, with the following advantages:


  • High dose PRP: CYTO-X PRP uses a high dose of platelets, up to 7-14 times higher than the normal concentration in blood. This ensures a maximal delivery of growth factors and cytokines to the injured area, as well as a high viscosity of the PRP, which improves its retention and distribution in the tissue.

  • Autologous concentrated growth factors and cytokines: CYTO-X PRP uses a special device that extracts and concentrates the growth factors and cytokines from your own blood. This enhances the potency and specificity of the PRP, as well as reduces the risk of infection or rejection.  One of the major cytokines extracted is called Interleukin-1 Receptor Antagonist (IL1-Ra).  This is a potent anti-inflammatory cytokines, which is also found in high concentrations in bone marrow.  Osteoarthritic joints contain catabolic and inflammatory cytokines, with two of the major ones called IL-1 and TNF-a.  IL-1Ra antagonises the effect of these inflammatory cytokines helping to promote an anabolic and healing environment within osteoarthritic joints and damaged tissues.

  • Low molecular weight, highly cross-linked hyaluronic acid: CYTO-X PRP uses a synthetic form of hyaluronic acid, a natural substance that lubricates and cushions the joints. The low molecular weight and high cross-linking of the hyaluronic acid increase its stability and durability in the tissue, as well as its compatibility with the PRP. The hyaluronic acid also provides a scaffold for the PRP, facilitating its integration and interaction with the tissue.


Why choose OrthoRegen for PRP therapy?


OrthoRegen® solely specialises in regenerative medicine and can tailor make PRP solutions for various conditions to optimise the patients’ outcomes. At OrthoRegen, you will benefit from:


  • A comprehensive assessment: We will conduct a thorough evaluation of your condition, including your medical history, physical examination, and imaging tests. We will also assess the factors that may affect your response to PRP, such as your blood quality, inflammation level, and tissue health.  

  • A personalised treatment plan: OrthoRegen® will design a treatment plan that suits your specific needs and goals. We will also advise you on the optimal number, frequency, and timing of the PRP injections, as well as the appropriate type of PRP for your condition. For example, OrthoRegen® may use leucocyte rich PRP (LR-PRP) for tendons and leucocyte poor PRP (LP-PRP) for joints, depending on the degree of inflammation and tissue damage.

  • A holistic approach: OrthoRegen® will not only treat the joint in osteoarthritis, but also look at things such as instability of ligaments, tendinopathies, and nerve related pain. We will treat the joint as an organ, rather than a simple joint injection. OrthoRegen® will also address the underlying causes and risk factors of your condition, such as biomechanical imbalances, nutritional deficiencies, and lifestyle habits.

  • An experienced physician: OrthoRegen® is led by Dr. Paul Schiavo, a fellowed physician with over 10 years of experience in cellular and regenerative therapies. Dr. Schiavo is a highly regarded expert in PRP and has performed over a thousand PRP injections for various musculoskeletal conditions. Dr. Schiavo is also a trainer and educator for other physicians who want to learn PRP techniques and protocols.

  • A state-of-the-art facility: OrthoRegen uses the latest technology and equipment for PRP therapy, such as a haematology analyser, a high end centrifuge, a growth factor extractor, and a hyaluronic acid injector. OrthoRegen® also uses advanced imaging techniques, such as ultrasound and fluoroscopy, to guide the PRP injections and ensure accuracy and safety.


What to expect from PRP therapy?


PRP therapy is a minimally invasive procedure that can be done in the office setting. The procedure typically takes about an hour and a half and involves the following steps:


  • Blood collection: A good amount of blood (about 120-180 mls) will be drawn from your arm using a sterile needle and syringe.

  • PRP preparation: The blood will be processed in a centrifuge via a proprietary two stage protocol, and a growth factor extractor, to separate and concentrate the platelets and their growth factors and cytokines. The PRP will then be mixed with the hyaluronic acid to form the CYTO-X PRP.  The Platelet Poor Plasma (PPP) component, which is usually discarded by other clinics, is filtered and concentrated, as it contains important elements such as fibrin, A2M and growth factors, that play an integral role in the healing process.

  • PRP injection: The CYTO-X PRP will be injected into the injured area using a fine needle and syringe under local anaesthetic. The injection will be guided by imaging techniques, such as ultrasound or fluoroscopy, to ensure accuracy and safety.

  • Post-procedure care: You will be advised to rest the treated area for a few days and avoid strenuous activities. You will also be given a follow-up and rehab protocol (if necessary) that includes exercises, stretches, and possibly supplements to enhance the healing and recovery process.


PRP therapy is not like a steroid or cortisone injection that provides immediate and temporary relief. PRP therapy is a regenerative treatment that stimulates the body's natural healing response and requires time and patience. The results of PRP therapy may vary depending on the severity and chronicity of your condition, as well as your individual response to the treatment. Some patients may notice improvement within a few weeks, while others may take several months to achieve optimal results. Either way, the OrthoRegen® team is there with you every step of the way to help you achieve the most optimal results.


How to get started with PRP therapy?


If you are interested in our CYTO-X PRP therapy and want to find out if you are a good candidate, you can contact OrthoRegen® to schedule a consultation.  You can also visit our CONTACT PAGE to complete the new patient documentation, which will be reviewed by Dr Schiavo to see if we can help treat your condition.  OrthoRegen® will provide you with a comprehensive assessment and a personalised treatment plan that will help you achieve your health and wellness goals. 

For further information on other services and treatments we provide, please head to OUR SERVICES page.

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