ORTHOREGEN'S® SECOND GENERATION PLATELET-BASED CELLULAR THERAPIES ARE ISOLATED FROM YOUR OWN BLOOD AND USED TO TREAT YOUR PAIN AND DYSFUNCTION.
OUR CUTTING EDGE TECHNOLOGY ALLOWS US TO UTILISE MANY ASPECTS OF YOUR BLOOD, SUCH AS CONCENTRATED CELLULAR COMPONENTS, CONCENTRATED GROWTH FACTOR COMPONENTS AND CONCENTRATED ANTI-INFLAMMATORY PROTEINS IN ORDER TO GIVE YOU THE BEST CHANCE OF HEALING AND RETURNING TO NORMAL ACTIVITIES WITH LIMITED RECOVERY TIME.
Platelets are small, colourless, disk-shaped cell fragments lacking a nucleus that are found in blood and play an imperative role in clot formation. They also have antimicrobial properties that support healing, infection control and the release of growth factors. These growth factors orchestrate the key biological processes required for healing. Most importantly, as it relates to healing, platelets also release numerous growth factors, including PDGF, TGF-β, VEGF, and SDF-1α, that have been shown to orchestrate the key biological processes, including angiogenesis, inflammation resolution and tissue regeneration.
Growth factors are necessary to initiate tissue repair at a wound site. Growth factors derived from platelets are responsible for soft tissue repair, bone regeneration, development of new blood vessels and stimulation of the wound healing process. The concentrated platelets we use may help optimise the conditions for healing.
Plasma is the fluid component of blood that contains water, vital proteins, salts, minerals, sugars, fats, hormones and vitamins. Recently, plasma has been found to carry beneficial anti-inflammatory proteins such as Interleukin-1 Receptor Antagonist and Alpha-2-Macroglobulin. These proteins are known to "shut off" mechanisms that lead to degeneration and catabolic inflammation in the body.
The concept behind the clinical use of these blood components is to harness the natural biological ability of a patient’s blood―primarily platelets―which may help optimise the conditions for healing, improve inflammatory response, control infection and promote angiogenesis.
Platelets facilitate healing through release of many growth factors actively involved in this process. Thus, PRP offers the physician an alternative to widespread treatments, such as steroid injections. Such treatments provide short-term relief by masking symptoms such as pain and inflammation that are the result of an injury, rather than actually addressing the cause of the injury directly through repair of damaged tissue.
Stem cells are at the core of the tissue regeneration process. They are required to rebuild and repair damaged tissue at an injury site. Platelets release several growth factors, such as SDF-1α, that function to induce migration of stem cells to the damaged tissue during the healing process. PRP provides these growth factors in high concentrations. In addition, some PRP preparations also contain stem cells isolated directly from the blood sample during processing, which can directly support tissue regeneration.
The PRP procedure is considered a simple and safe treatment.
A small amount of the patient’s blood is taken, just as a blood test would be performed. The blood is then spun in a centrifuge to separate and concentrate the platelets. We then analyse the PRP solution to make sure our patients are receiving the appropriate cellular concentration and cellular counts for their condition. This plasma highly concentrated with platelets, and other cells is then injected into the site of injury or tissue degeneration under ultrasound or fluoroscopy guidance with precise, advanced, minimally invasive techniques.
At OrthoRegen®, we believe each patient and injury is different. We do not support the use of PRP as a "one size fits all" treatment. This is because PRP utilises your own blood and this means there are variations between patients. We have the ability to individualise PRP treatments depending on the patient and the conditions we are treating. We integrate additional innovations like cytokine therapy, prolotherapy and musculoskeletal shockwave therapy to support our PRP treatments. We also incorporate ultrasound guidance to accurately inject PRP to the areas needing treatment.